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I recently got some prints framed. I've never hung anything that large up, but I found some helpful pages on the internet. I have plaster/lathe walls which are a little more difficult to nail than drywall.

Laura Jean Whitcomb: Getting the Hang of It:

It's a misconception that you have to find a stud in the wall to hang a picture. "You'll need a stud only for very large artwork, such as glass over 20-by-35 inches," says Korn.

"Picture hangers are meant to carry the weight of the picture. And use hangers -- nails will bend and your art will fall off the wall and crash."

"It is seldom necessary to find a wall stud in order to hang most pictures," agrees Kelly. "Even mirrors and larger pictures generally require no more than the appropriately sized picture hooks. Wall studs are only necessary when hanging framed oversized plate mirror or possibly cast metal or stone works that are extremely heavy. These items usually require steel cable rather than picture wire, and are usually hung from two or more heavy lag screws drilled directly into wall studs."

The classic brass hangers used to hang framed pieces are available in three sizes, and are capable of holding up to 40 pounds of weight. The 20- and 30-pound hangers take one nail, while the 40 pound takes two nails. If the artwork is large, AVA's Miller suggests using two hooks spaced apart to distribute the weight equally.

Helpful page about how to find a stud: Looking for Studs in All the Wrong Places: Six Ways to Find a Stud in Your Wall